Vistagen Announces Publication in Cells Demonstrating AV-101’s Potential for Treating Levodopa-Induced Dyskinesia in Patients with Parkinson’s Disease

Title: Vistagen’s AV-101 Shows Promise in Treating Levodopa-Induced Dyskinesia in Parkinson’s Disease Patients: Publication in Cells Highlights Potential Breakthrough


Parkinson’s Disease (PD) is a neurodegenerative disorder that affects millions of people worldwide, causing motor and non-motor symptoms that significantly impact quality of life. Levodopa, the gold standard medication for PD, can lead to a side effect known as levodopa-induced dyskinesia (LID), which further complicates treatment. In a recent publication in Cells, Vistagen Therapeutics announced significant findings regarding AV-101’s potential as a treatment option for LID in Parkinson’s patients. In this blog post, we will explore the key points of the study and the potential breakthrough it represents for PD treatment.

Key Points:

  1. Levodopa-Induced Dyskinesia (LID) and Parkinson’s Disease:
    LID is a common side effect associated with long-term levodopa treatment in Parkinson’s patients. It manifests as involuntary, often excessive, movements that can be both disabling and troublesome. Finding effective treatments for LID is crucial to improve the overall treatment of Parkinson’s disease.
  2. Vistagen Therapeutics and AV-101:
    Vistagen Therapeutics is a biopharmaceutical company focused on the development of innovative therapies for central nervous system disorders. AV-101, their lead drug candidate, is an oral NMDA receptor antagonist that has shown promise in preclinical studies for various neuropsychiatric indications.
  3. Study Publication in Cells:
    Vistagen’s recent publication in the peer-reviewed scientific journal Cells elucidates the potential efficacy of AV-101 in treating LID. The study’s findings provide encouraging evidence of the drug’s ability to alleviate LID symptoms in a preclinical model of PD.
  4. Mechanism of Action:
    AV-101’s mechanism of action involves modulating the activity of the NMDA receptor, regulating glutamate signaling in the brain. By targeting this pathway, AV-101 may counteract the abnormal dopamine release associated with levodopa, potentially mitigating LID symptoms.
  5. Study Results:
    According to the publication, AV-101 demonstrated the ability to significantly reduce LID severity without compromising the anti-Parkinsonian effects of levodopa. This suggests that AV-101 could be used as an adjunctive therapy to control LID symptoms while maintaining the efficacy of levodopa in managing the primary motor symptoms of Parkinson’s disease.
  6. Promising Implications for PD Treatment:
    Vistagen’s study findings are significant for Parkinson’s disease patients experiencing LID. The potential of AV-101 as an adjunctive therapy holds promise for improving their quality of life by reducing debilitating dyskinesia while preserving the positive effects of levodopa on motor symptoms.
  7. Future Clinical Trials:
    While the preclinical results are promising, further clinical trials will be necessary to validate the safety and effectiveness of AV-101 in PD patients with LID. The data from these trials will be crucial in determining whether AV-101 can progress towards becoming an approved treatment option for LID.


Vistagen Therapeutics’ publication in Cells showcasing AV-101’s potential in treating levodopa-induced dyskinesia in Parkinson’s disease patients marks a significant development in the field of PD therapeutics. The study provides preliminary evidence of AV-101’s ability to alleviate LID while maintaining the efficacy of levodopa for primary motor symptoms. These findings offer hope for improved management of LID symptoms and an enhanced quality of life for Parkinson’s patients. As research progresses and clinical trials are undertaken, we eagerly await further validation of AV-101’s potential and its eventual availability as a treatment option for LID in Parkinson’s disease.