AstraZeneca, Amgen’s asthma launch Tezspire picks up backing from England’s NICE

Title: AstraZeneca, Amgen’s Asthma Launch Tezepelumab Gains Support from England’s NICE


AstraZeneca and Amgen’s joint venture Asthma treatment, Tezepelumab, has received positive backing from England’s National Institute for Health and Care Excellence (NICE). The decision by NICE confirms the efficacy and safety of the new treatment by making it available through England’s public health system. In this blog, we will delve into the key points surrounding the positive endorsement by NICE.

Key Points:

  1. About Tezepelumab and its Mechanism of Action:

Tezepelumab is a monoclonal antibody that targets thymic stromal lymphopoietin (TSLP), a cytokine linked to the development and progression of asthma. TSLP activates several inflammatory pathways in the lungs, leading to airflow obstruction and other asthma symptoms. Tezepelumab’s specific mechanism of action aims to inhibit TSLP’s effects, potentially reducing inflammation and improving asthma control.

  1. Significance of NICE Backing:

The National Institute for Health and Care Excellence (NICE) in England has recommended Tezepelumab as an option for treating severe asthma in eligible patients. This backing signifies that the efficacy and safety of the drug have met the stringent standards required by NICE. It also means that eligible patients in England will have access to the drug through the National Health Service (NHS), expanding treatment options and improving patient outcomes.

  1. Impact on Patients and Healthcare Systems:

Tezepelumab’s approval by NICE has the potential to make a significant impact on patients with severe asthma and the healthcare systems that support them. Severe asthma affects people’s quality of life and has a significant impact on healthcare utilization and costs. Tezepelumab’s ability to reduce asthma symptoms and decrease exacerbations could improve patient outcomes and potentially reduce healthcare system costs.

  1. Future Developments and Advances:

Tezepelumab’s positive backing from NICE underscores the importance of continued progress in the field of asthma treatment and care. The approval highlights a continued focus on developing more targeted therapies that can address the underlying causes of asthma. It also underscores the importance of collaboration between pharmaceutical companies, healthcare providers, and regulatory authorities in advancing drug development and expanding treatment options.

  1. Importance of Addressing Severe Asthma:

Severe asthma represents a significant burden on both patients and healthcare systems. It is a chronic condition that affects millions of people worldwide and can lead to significant morbidity and mortality. The availability of effective treatments like Tezepelumab for severe asthma is vital in addressing this disease’s impact on public health. It also highlights the importance of continuing to research and develop targeted therapies that address the complex aspects of asthma pathogenesis.


NICE’s backing of Tezepelumab for severe asthma treatment signifies a significant advancement in asthma care. The drug’s unique mechanism of action and potential to reduce asthma symptoms and exacerbations offer hope for improved patient outcomes and reduced healthcare utilization and costs. Continued collaboration between pharmaceutical companies, healthcare providers, and regulatory authorities is vital in advancing drug development and expanding treatment options for severe asthma. Tezepelumab’s approval is a step forward in these collective efforts, offering further possibilities for improving asthma care and optimizing patient outcomes.